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Sources “The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis” Journal of Personalized Medicine (2021) “Vit B12 supplement of 500 μg/d for eight weeks does not normalize urinary methyl-malonic acid or other biomarkers of vitamin B12 status in elderly people” J Nutr

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The resulting decrease in antioxidant capacity and increased sorbitol accumulation cause osmotic damage to nerve cells, worsening neuropathy [181]

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